![]() ![]() ![]() Low-power electronic readout circuits 2 integrated into the device convert the light emitted by the encapsulated bacteria to a wireless signal. Leveraging the molecular specificity of living sensors 1, we genetically encoded bacteria to respond to inflammation-associated molecules by producing luminescence. Here we develop a miniaturized device that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track these molecules in the gastrointestinal tract. Owing to their highly reactive nature and extremely short lifetime in the body, these molecules are difficult to detect. Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide are key signals and mediators of inflammation. Nature volume 620, pages 386–392 ( 2023) Cite this article Sub-1.4 cm 3 capsule for detecting labile inflammatory biomarkers in situ ![]()
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